Harry is the latest generation of the Crumbs, famous and extremely talented detectives. Unfortunately, talent seems to have skipped a generation, and Harry is reduced to "gumshoe" work at a remote branch of the Crumb detective agency. Back at headquarters, Crumb executive Elliot Draison hatches an evil plan, which requires the inclusion of an incompotent detective. With Harry Crumb on the case, Draison thinks everything will run fine for him. Despite his best efforts, Crumb actually makes some headway in the case...

Clifford is a ten-year-old troublemaker, who puts not only his parents through hell, but also his uncle with whom his parents have discarded him to.